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. Author manuscript; available in PMC: 2020 Mar 11.
Published in final edited form as: Nat Cell Biol. 2019 Sep 2;21(9):1060–1067. doi: 10.1038/s41556-019-0384-4

Fig. 4 |. The cell cycle in neurogenesis.

Fig. 4 |

A decrease of CDK activity during neurogenic divisions enables the transactivation of proneural genes by a truncated form of Sox2 and Ngn2. Ngn2, in turn, inhibits the expression of G1 cyclins. A cell cycle inhibitor p27Kip1 stabilizes Ngn2, whereas p57Kip2 interacts with pro-neural factor Mash1 and represses its transcriptional activity. Rbl1 modulates the Notch pathway and affects the expression of its target genes. Abbreviations: NSC: neural stem cell.

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