Figure 5.
Inorganic arsenic (iAs) effects on the messenger RNA (mRNA) levels of ikkbα (A) and nfe2l2 (B) in the cortex of mice treated with 0, 5, or 14 mg/kg NaAsO2. For real-time PCR, total RNA was extracted from the brain cortex as described in “Materials and Methods” section. The data were normalized to the SDHA mRNA expression. The vertical bars indicate the mRNA levels relative to the control group. The bars represent the mean ± SE (n = 7). Different superscript symbols above each column indicate statistically significant differences; *P ≤ 0.05, **P ≤ 0.01, ***P < 0.001. Plus symbol denotes differences from the 2 h group, dagger symbol denotes differences from the 24 h group, two-way ANOVA with Tukey’s post hoc analysis. Significance was accepted at P ≤ 0.05.