Table 3.

Ex vivo Permeation Parameters of DH-TENVs Formulation versus DH Solution

Formulation No.	Lag Time (min)	Jss (µg/cm2.h)	Kp (cm/h)	EI
F1	75.32 ± 0.33	9.93± 0.71	0.0060± 0.0012	1.88
F2	38.65 ± 4.70	13.95± 1.00	0.0108± 0.0018	3.26
F3	29.34 ± 7.72	14.41± 0.96	0.0115± 0.0008	3.57
F4	57.33 ± 8.39	11.23± 1.04	0.0083± 0.0017	2.62
F5	38.38 ± 4.80	13.93± 1.00	0.0098± 0.0015	3.06
F6	69.77 ± 1.12	10.80± 1.13	0.0079± 0.0012	2.48
F7	82.42 ± 11.31	7.27± 0.63	0.0057± 0.0014	1.82
F8	23.14 ± 4.93	17.06± 0.90	0.0138± 0.0018	4.17
F9	43.72 ± 1.13	13.92± 0.92	0.0097± 0.0017	3.03
F10	26.86 ± 3.67	16.61± 0.96	0.0127± 0.0018	3.98
F11	25.44 ± 0.94	17.91± 0.91	0.0182± 0.0030	5.72
F12	38.82 ± 8.88	13.95± 0.84	0.0110± 0.0015	3.44
F13	28.85 ± 6.08	17.43± 1.12	0.0145± 0.0021	4.52
F14	49.37 ± 5.14	13.42± 1.00	0.0094± 0.0013	2.93
F15	15.31 ± 3.80	20.57± 1.25	0.0242± 0.0023	7.54
F16	50.47 ± 0.44	13.94± 0.80	0.0099± 0.0013	3.08
F17	65.42 ± 0.12	10.47± 0.90	0.0069± 0.0012	2.17
DH solution	91.10 ± 20.67	5.65± 0.71	0.0034± 0.0009	–

Note: Data are mean values (n = 3) ± SD.

Abbreviations: Jss, drug flux; Kp, permeability coefficient; EI, enhancement index.