Table 4.
Pharmacokinetic Parameters of DH in Rat Plasma After Administration of an Oral Solution, TENVs Loaded Gel, and Control Gel
| Pharmacokinetic Parameter | Oral DH Solution | TENVs Loaded DH gel | Control DH Gel |
|---|---|---|---|
| Cmax (ng/mL) | 197.61± 16.43 | 120.72± 9.50a | 32.27± 2.71a,b |
| tmax (h) | 1.50± 0.06 | 4.00± 0.55a | 3.00± 0.34a,b |
| t1/2 (h) | 5.46± 2.87 | 7.45± 1.32 | 9.24± 1.86 a |
| MRT (h) | 5.74± 1.56 | 11.97± 1.71a | 13.56± 2.04a |
| AUC0–24 (ng.h/mL) | 701.05± 25.81 | 1544.64± 130.82a | 353.82± 31.84a,b |
| AUC0–∞ (ng.h/mL) | 733.65± 51.08 | 1773.35± 171.05a | 426.33± 26.55a,b |
| Frel (%) | – | 242.99± 32.18 | 58.25± 4.17b |
Notes: Values are means ± SD, with the number of animals =6 for each group. ap < 0.05 versus oral DH solution. bp < 0.05 versus TENVs loaded DH gel. Using one-way ANOVA.