Fig 2. The dantrolene concentrations in the brain over time after intranasal vs oral administration.

There were no significant differences in the dantrolene brain/plasma ratios between intranasal and oral administration. The oral brain/plasma ratio fell to zero while the intranasal dantrolene brain/plasma ratio was sustained through 180 min. Data are expressed as Mean ± 95% CI, significance determined by multiple t-tests using the Holm-Sidak method with alpha = 5.00%. %. Intranasal time points, 10, 30, 150,180 min, n = 5; 20 min, n = 8; 50–120 min, n = 4; oral time points, 10–120 min; n = 5.