Fig 8. Schematic of reovirus entry and transport in neurons.

Reovirus entry in neurons is mediated by macropinocytosis and requires actin, dynamin, PI(3)K, and receptor tyrosine kinase (RTK). Following entry, multiple intact virions are transported together in non-acidified vesicles by dynein motors along microtubule tracks in the retrograde direction. Vesicle acidification in the soma triggers proteolytic disassembly of virions, which enables release of cores into the cytoplasm. Transcription of viral RNAs from cores leads to the establishment of viral replication factories or inclusions.