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. Author manuscript; available in PMC: 2020 Mar 11.
Published in final edited form as: Gynecol Oncol. 2015 Oct 31;140(1):184–190. doi: 10.1016/j.ygyno.2015.10.020

Table 1.

Study characteristics and association between body mass index and survival.

Study N Referent BMI Comparison BMI Hazard ratio Confidence interval p-Value Multivariate analysis Median follow-up Geographic setting
Akbayir 2012 3461 <25 25–30 0.82 0.15–4.29 0.81 Yes 59.1 months Turkey
>30 0.55 0.13–2.34 0.42
25–30 1.212 0.78–1.85
Arem 2013 983 <25 30–35 1.572 1.00–2.45 0.003 Yes 5.2 years United States3
>35 1.852 1.19–2.88
25–30 1.914 1.25–2.95 5.1 years United States5
Arem 2013 1400 18.5 < 25 30–35 2.124 1.37–3.29 <.001 Yes
>35 2.784 1.78–4.34
22 1.73 0.71–4.26
Bjorge 2010 287,320 20 24 1.45 0.59–3.57 <.001 Yes 10 years Norway, Austria, Sweden
26 1.99 0.85–4.67
32 5.35 2.43–11.8
25–29.9 1.5 1.26–1.78
Calle 2003 364,760 18.5 < 25 30–34.9 2.53 2.02–3.18 <.001 Yes 16 years United States6
35–39.9 2.77 1.83–4.18
≥40 6.25 3.75–10.4
Chia 2007 745 <25 25–29.9 1.2 0.8–2.0 0.05 Yes 9.3 years United States7
≥30 1.6 1.0–2.5
<18.5 1.018 0.13–7.76
25.0–29.9 1.008 0.56–1.79 United Kingdom, South Africa, Poland, New Zealand
Crosbie 2012 1070 18.5–24.9 30.0–34.9 0.848 0.44–1.61 0.38 Yes 34.3 months
35.0–39.9 0.628 0.27–1.42
≥40 1.178 0.49–2.76
Gates 2006 181 <25 >25 5.4 0.49–59.0 0.17 Yes Not given United States9
<18.5 3.42 0.75–15.6 0.17 Yes Not given Korea
Jeong 2010 937 <23 18.5 < 25 1.04 0.53–2.05
23≤25 0.93 0.37–2.29 0.70
≥25 0.87 0.41–1.83
Kodama 2005 242 <25 ≥25 0.425 0.14–1.32 0.07 No 54 months Japan
Martra 2008 766 ≥30 <30 1.04 1.01–1.07 <0.001 Yes 38 months Italy, Ohio
Mauland 2011 1129 ≥25 <25 0.9310 0.68–1.2710 0.6510 Yes 4.9 years Norway
25.0–29.9 0.96 0.69–1.33 0.81
Modesitt 2007 949 <25 30.0–39.9 1.33 0.96–1.84 0.08 Yes 13.6 months United States
≥40 1.86 1.16–2.99 0.01
Munstedt 2008 1180 NA11 NA11 0.98 0.95–1.00 0.09 No 6.2 years Germany
Rabischong 2011 207 <30 ≥30 0.835 .30–2.32 0.73 No 69–71 months France
<22.5 0.81 0.57–1.17
Reeves 2007 2657 22.5–24.9 25–27.4 1.09 0.82–1.45 Not Given Yes 7 years England, Scotland
27.5–29.5 1.21 0.85–1.71
≥30 2.28 1.81–2.87
Temkin 2007 442 <25 25.0 ≤ 30 0.16 0.14–0.19 0.003 Yes Not given United States12
≥30 0.16 0.14–0.18
von Gruenigen 2006 380 <30 30–39 1.47 0.81–2.67 0.21 Yes 65 months United States5
≥40 2.76 1.20–6.33 0.02
1

The total number of patients in the study was 370, but only 346 had information regarding body mass index.

2

The authors also included an age-adjusted model. The hazard ratios (HR) and confidence intervals (CI) were 1.19 (0.78–1.83), 1.43(0.92–2.22), and 1.86 (1.20–2.88) for women with BMI 25–30, 30–35, and >35 compared to BMI < 25, respectively (p = 0.004).

3

Geographic settings included California, Florida, Pennsylvania, New York, North Carolina, Arizona, Massachusetts, Washington D.C., Ohio, and Iowa.

4

Data presented was determined using a multivariate model adjusting for grade, stage, chemotherapy; and surgery. The authors also included a second model adjusting for grade, stage, race, chemotherapy, surgery, smoking, diabetes, and family history of breast cancer. Using this model the hazard ratios (HR) and confidence intervals (CI) were 1.74 (1.13–2.66), 1.84(1.17–2.88), and 2.35 (1.48–3.73) for women with BMI 25–30, 30–35, and >35 compared to BMI < 25, respectively (p < 0.001).

5

Geographic settings included California, Florida, Pennsylvania, New Jersey, North Carolina, Louisiana, Georgia, Michigan, Texas, Arizona and Nevada.

6

Geographic settings within the United States, not further specified.

7

Geographic setting: Wisconsin.

8

The data represents survival outcomes for women with Type I endometrial cancer. The authors also included a separate analysis for women with Type II endometrial cancers. The hazard ratios (HR) and confidence intervals (CI) were 0.96 (0.46–2.02), 0.76 (0.31–1.87), and 0.88 (0.33–2.35) for women with BMI 25–29.9, 30–34.9, and 35.0–39.9 compared to BMI 8.5–24.9, respectively (p = 0.664).

9

Geographic setting: Georgia.

10

Only data from the adjusted analysis is listed.

11

BMI was only evaluated as a continuous variable.

12

Geographic setting: New York.