Table 2. Results of PERMANOVA analysis investigating the effect of the interaction between disease signatures and age-group, after adjusting for the effects of country (within the continent cohorts) and the independent effects of disease and age-group.
| Adonis | T2D | IBD | CRC | Polyps | Cirrhosis | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| F.Model | R-Squared | P-Value | F.Model | R-Squared | P-Value | F.Model | R-Squared | P-Value | F.Model | R-Squared | P-Value | F.Model | R-Squared | P-Value | |
| Country | 16.69 | 0.029 | 0.001 | 11.34 | 0.017 | 0.001 | 7.63 | 0.027 | 0.001 | 4.65 | 0.022 | 0.001 | NA | NA | NA |
| Disease | 4.81 | 0.008 | 0.001 | 15.79 | 0.023 | 0.001 | 4.70 | 0.008 | 0.001 | 1.25 | 0.006 | 0.028 | 12.107 | 0.029 | 0.001 |
| Age-Group | 1.38 | 0.005 | 0.001 | 2.51 | 0.007 | 0.001 | 3.80 | 0.007 | 0.001 | 1.00 | 0.004 | 0.408 | 1.239 | 0.006 | 0.016 |
| Disease:Age-Group | 1.12 | 0.004 | 0.08 | 2.73 | 0.008 | 0.001 | 3.57 | 0.006 | 0.001 | 1.38 | 0.006 | 0.011 | 1.035 | 0.005 | 0.290 |