Table 1. Protein components of the flagellar filament from Leptospira.
| Protein | Mol. weight | Putative localization in spirochete filaments |
Gene names Leptospira biflexa (Uniprot ID) |
Gene names Leptospira interrogans (Uniprot ID) |
Protein copies per cell in L. interrogans (Malmström et al., 2009) |
Sequence homologies |
|---|---|---|---|---|---|---|
| FlaB1 | ~31 kDa | Core | LEPBIa2133 (B0SSZ5) | LIC11890 (Q8F4M3) | ~14,000 | • The four FlaB isoforms are homologous to domains D0+D1 of S. enterica flagellin FliC. • FlaB1, FlaB2 and FlaB4 are ~ 65–70% identical to each other in both Leptospira species. • L. biflexa FlaB1 is ~ 87% identical to L. interrogans FlaB1. |
| FlaB2 | ~31 kDa | Core | LEPBIa2132 (B0SSZ4) | LIC11889 (Q72R59) | ~2000 | • L. biflexa FlaB2 is ~ 78% identical to L. interrogans FlaB2. |
| FlaB3 | ~31 kDa | Core | LEPBIa1872 (B0SS86) | LIC11532 (Q72S54) | ~300 | • FlaB3 is ~ 50–55% identical to the other three isoforms in both Leptospira species. • L. biflexa FlaB3 is ~ 62% identical to L. interrogans FlaB3. |
| FlaB4 | ~31 kDa | Core | LEPBIa1589 (B0SQZ5) | LIC11531 (Q72S55) | ~3500 | • L. biflexa FlaB4 is ~ 92% identical to L. interrogans FlaB4. |
| FlaA1 | ~36 kDa | Sheath | LEPBIa2335 (B0SKT4) | LIC10788 (Q72U74) | ~4500 | • The two FlaA isoforms are not homologous to FlaB or other bacterial flagellins. • FlaA1 and FlaA2 are ~ 25–28% identical in bothLeptospira species. • L. biflexa FlaA1 is ~ 56% identical to L. interrogans FlaA1. |
| FlaA2 | ~27 kDa | Sheath | LEPBIa2336 (B0SKT5) | LIC10787 (Q72U75) | ~3500 | • L. biflexa FlaA2 is ~ 70% identical to L. interrogans FlaA2. |
| FcpA | ~36 kDa | Sheath | LEPBIa0267 (B0STJ8) | LIC13166 (Q72MM7) | ~8000 | • FcpA is unique to the Leptospira genus. • FcpA and FcpB are not homologous. • L. biflexa FcpA is ~ 77% identical to L. interrogans FcpA. |
| FcpB | ~32 kDa | Sheath | LEPBIa1597 (B0SR03) | LIC11848 (Q72RA0) | ~4000 | • FcpB is unique to the Leptospira genus. • L. biflexa FcpB is ~ 53% identical to L. interrogans FcpB. |