Figure 6.
TUG1 regulates ovarian cancer PTX resistance in vivo. (A) NC or si-TUG1 was transfected into A2780/R cells, which were injected into nude mice (n = 6). When the tumor size reached a volume of approximately 50 mm3, the mice were treated with PTX twice per week. (B) The tumor size of the mice was monitored every four days using student’s t test analysis. (C) Tumor weights are represented as the means of tumor weight per group using student’s t test analysis (p=0.0005). (D) qPCR was performed to detect the average expression of TUG1 and miR-29b-3p using one-way ANOVA analysis (p<0.05). *p<0.05; **p<0.01 and ***p<0.001.
Abbreviations: TUG1, taurine up-regulated 1; PTX, Paclitaxel; Si-NC, small interfering RNA negative control; qRT-PCR, qualitative real-time polymerase chain reaction; Si, Small interfering RNA; NC, negative control.