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. Author manuscript; available in PMC: 2021 Mar 1.
Published in final edited form as: Pharm Stat. 2019 Nov 6;19(2):137–144. doi: 10.1002/pst.1974

FIGURE 2.

FIGURE 2

Simulated trial example of the Bayesian optimal interval method and the Keyboard method for n = 36 patients under Scenario 3 in Table S2 of Zhou et al8. Red circles denote incoherent dose assignments. DLT = dose-limiting toxicity; MTD = maximum tolerated dose.