Skip to main content
. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Expert Opin Drug Discov. 2020 Jan 3;15(4):427–441. doi: 10.1080/17460441.2020.1703671

Figure 1. Application of human induced pluripotent stem cell-derived neurons for disease modeling and drug discovery in Parkinson’s disease.

Figure 1.

Human somatic cells such as fibroblasts or peripheral blood mononuclear cell (PBMC) from healthy control, familial and sporadic PD patients are reprogrammed into human iPSCs. Human iPSCs are further differentiated into dopamine neurons or 3D brain organoid depending on the purpose. Differentiated tissues enable replication of Parkinson’s disease in vitro and can be further used for disease modeling, drug discovery and dopamine replacement stem cell therapy.