Table 2:

Drug Discovery in Parkinson’s Disease iPSC DA Neurons

Tested drug	Target	Mode of action	Reference
NCGC758 NCGC607	β-Glucocerebrosidase (GCase)	Small-molecule chaperone	Aflaki et al 2016; Mazzulli et al 2016) [127, 132]
Quinazoline inhibitors	β-Glucocerebrosidase (GCase)	Selective stabilization of GCase	Zheng et al 2019 [159]
Carmofur	Acid ceramidase	Inhibitor	Kim et al 2018 [160]
S-181	β-Glucocerebrosidase (GCase)	Increased wild-type GCase activity	Burbulla et al 2019 [134]
mito-TEMPO NAC	Mitochondria	Antioxidants	Burbulla et al. 2017 [12]
Isoxasole	MEF2C	Activator	Ryan et al. 2013 [61]
PD0325901	MEK	Inhibitor	Reinhardt et al 2013 [78]
NPT100–18A NPT100–14A ELN48228	α-synuclein	Interfering oligomerization	Kouroupi et al 2017 [62]