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. Author manuscript; available in PMC: 2020 Aug 3.
Published in final edited form as: Nat Neurosci. 2020 Feb 3;23(3):375–385. doi: 10.1038/s41593-019-0578-x

Extended Data Fig. 10. Mouse concordant ASD genes (CAGs) are not convergent with Schizophrenia or Down Syndrome.

Extended Data Fig. 10

(A) The eigengene of the CAGs found across the three models of syndromic ASD explains 65.8% of the gene expression variance and is not associated with Schizophrenia diagnosis (linear regression two-sided p-value=0.538). (B) The eigengene of the CAGs found across the three models of syndromic ASD explains 53.2% of the gene expression variance and is not associated with Down Syndrome diagnosis (linear regression two-sided p-value=0.34). (C)Estimated cellular composition differences between patients with schizophrenia and controls using reference-based deconvolution. There were significant increases of astrocytes (p=0.0002) and endothelial cells (p=0.0118) and decreases in microglia (p=0.0076) in patients with schizophrenia compared to controls using linear regression analysis.