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. Author manuscript; available in PMC: 2020 Aug 3.
Published in final edited form as: Nat Neurosci. 2020 Feb 3;23(3):375–385. doi: 10.1038/s41593-019-0578-x

Figure 8: Human-mouse convergence of gene expression in idiopathic and syndromic ASD.

Figure 8:

(A) The eigengene of the CAGs found across the three models of syndromic ASD in Parikshak et al is significantly associated with ASD but not 15q duplication diagnoses (via linear mixed effects modeling). (B). The CAG eigengene is also different between patients with ASD from controls in Wright et al. as replication (linear regression for ASD p=0.0411). Estimated cellular composition differences between patients with ASD and controls using reference-based deconvolution show decreased OL RNA fractions in (C) Parikshak et al (linear mixed effects regression for ASD p=0.0004) and (D) Wright et al (linear regression for ASD p=0.0281). The y-axis in each panel are residualized values when accounting for observed and latent confounders for improved visual interpretation (see Methods).