Skip to main content
. Author manuscript; available in PMC: 2020 Aug 17.
Published in final edited form as: Nat Neurosci. 2020 Feb 17;23(3):327–336. doi: 10.1038/s41593-020-0589-7

Extended Data Fig. 4. GBA1 gene transfer increases GCase function and improves GI health.

Extended Data Fig. 4

a-d, Characterization of GI function before and after peripheral GBA1 gene transfer by quantifying fecal pellet production (b), fecal pellet weight (c; ASO 0 vs. 60 dpvi *p = 0.0265), proportion fecal water weight (d), and whole gut fecal transit time (e). e-h, Characterization of GI function before and after peripheral EGFP gene transfer by quantifying fecal pellet production (e), fecal pellet weight (f), proportion fecal water weight (g), and whole gut fecal transit time (h; 0 dpi WT vs. ASO **p = 0.0085, 60 dpi WT vs. ASO *p = 0.0293). Data depicted are mean ± s.e.m. P values were determined by two-way ANOVA (a-h). The following n values represents number of independent animals used for statistical evaluation: e4a-d, for 0 / 7 / 21 / 60 dpi: WT = 17 / 12 / 11 / 8, ASO = 13 / 12 / 11 / 10; e4e-h, all conditions = 4 each.