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. Author manuscript; available in PMC: 2020 Aug 17.
Published in final edited form as: Nat Neurosci. 2020 Feb 17;23(3):327–336. doi: 10.1038/s41593-020-0589-7

Extended Data Fig. 9. Duodenal αSyn PFF inoculation in aged mice does not result in SNc dopaminergic cell loss.

Extended Data Fig. 9

a-c, Representative images of the midbrain immunostained for dopaminergic neurons (TH), S129P, and nuclei (DAPI) from aged mice pre-inoculation (a), α-Syn PFF-inoculated aged mice 120 dpi, and α-Syn-monomer inoculated aged mice 120 dpi. Scale bars, 500 μm. Experimental images for (a-c) were obtained from 12 independent mice, with similar results obtained. d, Quantification of dopaminergic cell density within the boundary of the SNc as determined by TH+ signal (example shown in [a]). Data depicted is mean ± s.e.m. P values were determined by one-way ANOVA. The following n values represents number of independent animals used for statistical evaluation: e9d, all conditions = 4.