Table 3.
The potential for metabolite markers in the diagnosis of BC
| Ref. | Sample | Sensitivity | Specificity | AUC | Potential Biomarker(s) | Note |
|---|---|---|---|---|---|---|
| Baowen Yuan 9(2019) | plasma | - | - | 0.870 | all significant metabolites | BC vs HC(training) |
| - | - | 0.800 | all significant metabolites | BC vs HC(validation) | ||
| Paniz Jasbi 13(2019) | plasma | 80.00% | 75.00% | 0.890 | all significant metabolites | BC vs HC |
| - | - | 0.760 | proline | BC vs HC | ||
| 86.00% | 75.00% | 0.870 | all significant metabolites | EBC vs HC | ||
| Dan Tudor Eniu 14(2019) | serum | 83.33% | 76.92% | 0.850 | isoleucine | BC vs HC |
| 66.67% | 92.31% | 0.850 | tryptophan | BC vs HC | ||
| Xinyang Wang 15(2018) | serum | - | - | 0.924 | glutamic acid | BC vs HC |
| - | - | 0.901 | taurine | BC vs HC | ||
| - | - | 0.749 | ethylmalonic acid | BC vs HC | ||
| Shankar Suman 17(2018) | plasma | - | - | 0.818 | β-glucose | BC vs HC |
| - | - | 0.780 | α-glucose | BC vs HC | ||
| - | - | 0.780 | lactate | BC vs HC | ||
| - | - | 0.697 | hydroxybutyrate | BC vs HC | ||
| - | - | 0.652 | N-acetyl glycoprotein | BC vs HC | ||
| - | - | 0.627 | lysine | BC vs HC | ||
| Tushar H. More 18(2018) | tissue | - | - | 0.970 | guanine | IDC vs HC |
| - | - | 0.830 | tyrosine | IDC vs BE | ||
| - | - | 0.960 | tyrosine | IDC vs HC | ||
| serum | - | - | 0.980 | ascorbic acid | IDC vs HC | |
| - | - | 0.830 | uridine diphosphate | IDC vs BE | ||
| Mónica Cala 22(2018) | urine | 93.50% | 86.20% | 0.915 | dimethylheptanoylcarnitine +succinic acid | BC vs HC |
| Mariona Jové 24(2017) | plasma | 100.00% | 100.00% | 1.000 | C26H43ClN4S3 | BC vs HC |
| 100.00% | 100.00% | 1.000 | C26H51N5O4 | BC vs HC | ||
| 100.00% | 100.00% | 1.000 | C9H16O3S | BC vs HC | ||
| 100.00% | 100.00% | 0.999 | C23H30N2S | BC vs HC | ||
| 100.00% | 100.00% | 0.995 | caproic acid | BC vs HC | ||
| 100.00% | 90.00% | 0.952 | taurine | BC vs HC | ||
| 90.00% | 90.00% | 0.959 | stearamide | BC vs HC | ||
| 100.00% | 90.00% | 0.935 | linoleic acid | BC vs HC | ||
| Naila Irum Hadi 25(2017) | serum | 96.00% | 100.00% | 0.990 | all significant metabolites | BC vs HC |
| Liping Zhong 26(2016) | saliva | 92.60% | 91.70% | 0.929 | MG(0:0/14:0/0:0) | BC vs HC |
| 77.80% | 100.00% | 0.920 | LysoPC (18:1) | BC vs HC | ||
| 81.50% | 91.70% | 0.920 | LysoPC (22:6) | BC vs HC | ||
| Qingjun Wang 27(2016) | serum | 90.30% | 87.40% | 0.944 | all significant metabolites | BC vs BE(HC) |
| Takahiro Takayama 28(2016) | saliva | 68.90% | 74.40% | 0.744 | spermine. | BC vs HC |
| Luisa Matos Do Canto 29(2016) | ductal fluid | 90.70% | 88.40% | 0.956 | all significant metabolites | BC vs HC |
| Sijia Huang 30(2016) | plasma | - | - | 0.986 | all significant metabolites | BC vs HC(training) |
| - | - | 0.995 | all significant metabolites | EBC vs HC(training) | ||
| - | - | 0.923 | all significant metabolites | BC vs HC(testing) | ||
| - | - | 0.905 | all significant metabolites | EBC vs HC(testing) | ||
| serum | - | - | 0.995 | all significant metabolites | BC vs HC(validation) | |
| - | - | 0.902 | all significant metabolites | EBC vs HC(validation) | ||
| Guoxiang Xie 32(2015) | plasma | 100.00% | 100.00% | 1.000 | aspartic acid | BC vs HC(training) |
| 100.00% | 94.30% | 0.996 | glycerolphosphate | BC vs HC(training) | ||
| plasma | 85.40% | 95.10% | 0.935 | aspartic acid | BC vs HC(validation) | |
| 95.10% | 93.20% | 0.971 | glycerolphosphate | BC vs HC(validation) | ||
| Yunping Qiu 35(2013) | plasma | 98.10% | 96.00% | - | LysoPC a C16:0, PC ae C42:5 and PC aa C34:2 | BC vs HC |
| Tone F. Bathen 37(2013) | tissue | 91.00% | 93.00% | - | all significant metabolites | BC patientstumor tissue vs non-involved adjacent tissue |
| Wuwen Lv 38(2012) | serum | 82.80% | 85.30% | 0.892 | C16:0 | BC vs HC |
| 89.70% | 85.00% | 0.925 | C16:0 | BC vs BE | ||
| Yohei Miyagi 41(2011) | plasma | - | - | 0.778 | all significant metabolites | BC vs HC |
| - | - | 0.813 | all significant metabolites | Stage 0 BC vs HC | ||
| - | - | 0.754 | all significant metabolites | Stage I BC vs HC | ||
| - | - | 0.786 | all significant metabolites | Stage II BC vs HC | ||
| - | - | 0.755 | all significant metabolites | Stage III BC vs HC | ||
| Masahiro Sugimoto 42(2010) | saliva | - | - | 0.973 | all significant metabolites | BC vs HC |
| Carolyn M. Slupsky 43(2010) | urine | 100.00% | 93.00% | - | all significant metabolites | BC vs HC |
| Hojung Nam 45(2009) | urine | - | - | 0.790 | all significant metabolites | BC vs HC |