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. 2020 Feb 19;11(9):2679–2687. doi: 10.7150/jca.40974

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STAT3/AKT branch is activated in A375 and M14 cells under IL22 teatment. (A) The target sequence of miR-181 in 3'UTR region of STAT3. (B) Luciferase activities of reporter vectors in A375 and M14 cells. (C) Expression of STAT3 in A375 and M14 cells under ad-sh-miR-181 treatment. (D) Expression of p-AKT, p-β-catenin, and MMP-4 in A375 and M14 cells under IL22 and ad-sh-miR-181 treatment. *P<0.05 verse control group, ^#P<0.05 verse IL22+shNC group.