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. 2020 Feb 10;11(9):2496–2508. doi: 10.7150/jca.41415

Figure 1.

Figure 1

Identification of prognostic related genes in lung adenocarcinoma. A. By analysis of GEO and TCGA datasets, volcano plots showed significantly different expressed genes (DEGs) between LUAD tissues and normal controls. Venn digram further revealed the number of common up-regulated DEGs and down-regulated DEGs among the four datasets. B. Fifty-four hub genes screened out from Cytosacpe cytoHubba plug-in and 19 up-regulated hub genes intersected by R software. C. Kaplan-Meier survival analysis was performed to analyze 504 LUAD patients in TCGA and found that the expression level of TOP2A (P = 0.0063) was inversely associated with the prognosis of LUAD patients and the result was validated in GSE31210 by pronoScan online database (P = 0.0039). D. We identified the expression of TOP2A in 517 LUAD cases and 59 normal tissues in TCGA, which showed TOP2A was significantly highly expressed in lung adenocarcinoma. The result was validated by GSE116959 (tumor = 57, normal = 11), which found TOP2A was overexpressed in LUAD (P = 0.0039). E. The boxplots showed the relationship between clinicopathological parameters and TOP2A expression, which revealed that the expression of TOP2A was not associated with the age (P = 0.6), gender (P = 0.18), and TNM stage (P = 0.35) of patients.