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. 2020 Feb 10;11(9):2496–2508. doi: 10.7150/jca.41415

Figure 2.

Figure 2

Validation of TOP2A expression in lung adenocarcinoma cell lines and tissues. A. TOP2A expression was performed with Western blot in lung adenocarcinoma cells (A549, LTEP-A2 and GLC82) and normal human bronchial epithelium cell (BEAS-2B). The expression levels of GLC82 and A549 were higher than LTEP-A2 and BEAS-2B; B. TOP2A expression was detected in protein and mRNA levels in 8 lung adenocarcinoma tissues and paired adjacent normal tissues. TOP2A expression was higher in tumor than adjacent normal tissues; C. Representative immunohistochemical imagines for TOP2A in 84 patients with primary lung adenocarcinoma. Original magnification:200× and 400×; D. Correlation analysis between the expression of TOP2A (low and high expression) and recurrence-free survival, overall survival in AD patients by Kaplan-Meier survival curve estimation. TOP2A high expression is related to prognosis. *<0.05.