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. 2020 Feb 14;11(9):2593–2601. doi: 10.7150/jca.38449

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This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/). See http://ivyspring.com/terms for full terms and conditions.

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The roles of miR-30c family members in carcinogenesis, metastasis and invasion. Note: miR-30c promotes cancer progression through the activation of KRAS/MAPK signal pathway, and miR-30c family members act as caner suppressors by targeting TWF1 (Twinfilin actin binding protein 1)-IL-11-STAT3 pathway. Moreover, cancer metastasis and invasion were inhibited by the decreased EMT process caused by the down-expression leves ofMTDH(Metadherin) and VIM (Vimentin) via the specific bindings of miR-30c, respectively.