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. 2020 Feb 13;20:97–110. doi: 10.1016/j.omtn.2020.02.006

Figure 6.

Figure 6

miR-101-3p Mimic Attenuated the RC3H2 Overexpression-Induced Aggressive Behaviors of OSCC Cells

(A) The upregulation of EZH2 and H3K27Me3 protein levels by RC3H2 overexpression was partially reversed through miR-101-3p mimic in HN4 and Cal27 cells. (B and C) The cell proliferation of HN4 (B) and Cal27 (C) cells co-transduced with LV-NC plus miR-NC, LV-RC3H2 plus miR-NC, LV-NC plus miR-101-3p mimic, or LV-RC3H2 plus miR-101-3p mimic were evaluated by CCK-8 assays. (D) The colony-forming abilities of HN4 and Cal27 cells co-transduced with LV-NC plus miR-NC, LV-RC3H2 plus miR-NC, LV-NC plus miR-101-3p mimic, or LV-RC3H2 plus miR-101-3p mimic were determined by colony-formation assays. (E) The invasion abilities of HN4 and Cal27 cells co-transduced with LV-NC plus miR-NC, LV-RC3H2 plus miR-NC, LV-NC plus miR-101-3p, mimic or LV-RC3H2 plus miR-101-3p mimic were performed by Transwell assays. Data are presented as mean ± SD from three independent experiments (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001).