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. 2019 Jul 5;15(1):26–41. doi: 10.1016/j.ajps.2019.06.001

Fig. 2.

Fig 2

Schematic illustration of the mechanisms of action of ACLEP to overcome hypoxia-triggered erlotinib resistance. ACLEP could achieve oxygen and drug co-delivery and regulate the expression of HIF-1a in hypoxic microenvironment in both EGFR-wild and EGFR-mutated NSCLC.