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. 2020 Mar 5;10:180. doi: 10.3389/fonc.2020.00180

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Copyright © 2020 Zheng, Li, Lei, Liu, Wang, Fei, Yang, Huang and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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FAM83A enhances the proliferative and invasive abilities of lung cancer cells by the Wnt signaling pathway. (A) The cell growth curve of H1299 cells transfected with FAM83A, and their control cells were added with DMSO or XAV-939. (B,C) Representative images of the colony formation assay for H1299 cells transfected with FAM83A, and their control cells were added with DMSO or XAV-939 (B). The number of colonies formed by each group is shown in the histogram (C). (D,E) Representative images of the Matrigel invasion assay for H1299 cells transfected with FAM83A, and their control cells were added with DMSO or XAV-939 (D). The invasive cell number for each group is shown in the histogram (E). *P < 0.05, **P < 0.01, ***P < 0.001, NC, negative control cells; FAM83A, cells transfected with FAM83A; DMSO, dimethyl sulfoxide; XAV-939, an inhibitor of Wnt/β-catenin signaling; *NC+DMSO vs. FAM83A+DMSO; *FAM83A+DMSO vs. FAM83A+XAV-939.