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. 2020 Mar 5;10:180. doi: 10.3389/fonc.2020.00180

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Copyright © 2020 Zheng, Li, Lei, Liu, Wang, Fei, Yang, Huang and Xu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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A proposed model to illustrate the role of FAM83A in the Wnt and Hippo signaling pathways. GSK3β phosphorylates β-catenin and results in the degradation of β-catenin, which inhibits the activity of the Wnt signaling pathway. FAM83A can inhibit GSK3β activity and increase the level of active unphosphorylated β-catenin; active β-catenin then transports into the nucleus and activates the Wnt signaling pathway. Meanwhile, similar to β-catenin, FAM83A may also inhibit the phosphorylation and degradation of YAP, which is induced by the Hippo signaling pathway and enhance the activity of YAP through repressing GSK3β. In addition, FAM83A could downregulate the upstream MST to inhibit the activation of the Hippo signaling pathway. Figures were produced using Servier Medical Art (https://smart.servier.com).