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. 2020 Jan 15;10(2):425–439. doi: 10.1007/s13346-019-00683-6

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — Dose-normalized NAGLU tissue levels show superior biodistribution in cynomolgus monkey following ICV delivery (n = 3, light bars) relative to IV delivery (n = 2, dark bars) in perfused brain samples collected 48 h after a single dose of BMN 250. Concentrations shown are the measured NAGLU concentration relative to total protein in each sample, normalized to the amount of BMN 250 (mg) dosed. Error bars = SD