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. 2020 Jan 15;10(2):425–439. doi: 10.1007/s13346-019-00683-6

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© The Author(s) 2020

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Fig. 7 — (a) Representative staining from superficial medulla oblongata from cynomolgus monkey administered BMN 250 via the IV route. All NAGLU (green) staining is colocalized with CD31 (red) positive endothelial cells, indicating administered NAGLU does not reach target neurons. (b, c) 20× image with zoom of subfornical organ, showing extravascular NAGLU in a region with less BBB tight junctions. Scale bars = 20 μm