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. 2020 Mar 5;10:265. doi: 10.3389/fonc.2020.00265

Figure 1.

Figure 1

Membrane localization of P-glycoprotein (P-gp, PDB ID: 6QEX). (A) Kyte-Doolittle hydropathy plot determining the amino acid positions in the twelve transmembrane domains (TMD) of P-gp (https://embnet.vital-it.ch/cgi-bin/TMPRED_form_parser; EXPASy Bioinformatics resource portal); (B) Schematic of the membrane localization of 12 TMDs, 2 ATP- nucleotide binding domains (NBD), and 3 most common single nucleotide polymorphisms (SNP) on P-gp; (C) Tertiary three dimensional inverted V-shaped structure of P-gp.