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. 2020 Mar 5;11:193. doi: 10.3389/fgene.2020.00193

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Copyright © 2020 Liu, Zou, Li, Yang, Ye, Zhang, Wei and Kong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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circGNB1 is upregulated in TNBC and correlated with poor clinical outcomes. (A) The expression level of circGNB1 in normal mammary cell line MCF-10A and breast cancer cell lines. Gray bar and black bar represent for TNBC and non-TNBC cell lines, respectively. (B,C) Kaplan–Meier analysis of the (B) overall survival and (C) disease-free survival of 222 TNBC patients with circGNB1 high (green) or low (blue) expression levels. (D) Relative abundance of circGNB1 and GNB1 mRNA after treatment with RNase R in MDA-MB-231 cells. (E) Relative abundance of circGNB1 and GNB1 mRNA after being treated with Actinomycin D in BT-549 cells.