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. 2020 Mar 5;11:193. doi: 10.3389/fgene.2020.00193

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Copyright © 2020 Liu, Zou, Li, Yang, Ye, Zhang, Wei and Kong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Downregulation of circGNB1 suppresses the proliferation and metastasis of TNBC cells in vitro. (A) Efficacy of siRNA targeting circGNB1 was assessed by qRT-PCR analysis. (B,C) circGNB1 inhibits the colony forming ability of MDA-MB-231 and BT549 cells. (D) Cell proliferation was detected by CCK-8 assays. (E) Wound-healing assays assessed the impact of circGNB1 on cell migration ability. (F) Mouse xenograft models were established. (G) Tumor weight were measured and recorded. (H) Hematoxylin-eosin staining was conducted and sections of lung metastases are showed. (I) The number of lung metastases was counted and recorded. *P < 0.05; **P < 0.01.