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. 2020 Mar 5;11:193. doi: 10.3389/fgene.2020.00193

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Copyright © 2020 Liu, Zou, Li, Yang, Ye, Zhang, Wei and Kong.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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circGNB1 functions as a sponge of miR-141-5p. (A) Predicted binding site of miR-141-5p within circGNB1 according to MRE. (B) Kaplan-Meier analysis of the association between miR-141-5p and overall survival in patients with triple negative breast cancer from TCGA public online database (http://kmplot.com/analysis). (C) U6 (nuclear control transcript), GAPDH (cytoplasmic control transcript) and circGNB1 in nuclear and cytoplasmic fractions analyzed by qRT-PCR. (D–E) Luciferase reporter assays of MDA-MB-231 and BT549 cells co-transfected with miR-141-5p mimics and circGNB1 wild type or mutant luciferase reporter plasmid. (F) The colony formation ability enhanced by miR-141-5p inhibitors were reversed after co-transfected with si-circGNB1 using colony formation assay. *P < 0.05; **P < 0.01.