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. 2020 Mar 5;11:193. doi: 10.3389/fgene.2020.00193

TABLE 2.

Univariate and multivariate Cox regression analysis of circGNB1 and survival in patients with triple-negative breast cancer.

Parameter Univariate analysis Multivariate analysis


HR 95% CI P-value HR 95% CI P-value
Age (>50 vs. ≤50 years) 0.632 0.304–1.312 0.219 NA
Menopause (Yes vs. No) 0.670 0.329–1.362 0.258 NA
Histological grade (G3 vs. G1-2) 1.434 0.740–2.782 0.286 NA
Tumor size (>2.0 cm vs. ≤2.0 cm) 3.141 1.110–8.889 0.013* 2.072 0.708–6.064 0.184
Lymph node status (Positive vs. Negative) 2.807 1.350–5.836 0.006* 1.514 0.645–3.553 0.340
TNM stage (III–IV vs. I–II) 3.365 1.740–6.510 0.001* 2.703 1.360–5.373 0.005*
circGNB1 expression (High vs. Low) 2.759 1.409–5.404 0.003* 2.148 1.070–4.310 0.031*

NA: not analyze; *P < 0.05, statistically significant.