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. 2020 Mar 11;10:4510. doi: 10.1038/s41598-020-61315-5

Figure 1.

Figure 1

Chilean H1 swine IAVs are genetically distant from North American commercial vaccine strains. Phylogenetic tree based on HA1 domain nucleotide sequences of H1 swine IAVs, obtained using the Maximum Likelihood method and General Time Reversible model with a variation rate among sites given by gamma distribution with invariant sites (GTR + G + I). Five hundred eighty-nine sequences were used to construct this phylogenetic tree. Chilean swine IAVs (including reference sequences) are grouped in three phylogenetic clusters: Chilean H1A (ChH1A; blue), Chilean H1B (ChH1B; purple) and pandemic H1N1 2009-like (A(H1N1)pdm09-like; green). Reference sequences from human seasonal IAVs (1977–2008) are in red, and North American H1 swine clusters (α clade 1A.1; β clade 1A.2; γ clades 1A.3.2 and 1A.3.3.3; δ clades 1B.2.1, 1B.2.2, 1B.2.2.1 and 1B.2.2.2; and A(H1N1)pdm09-like clade 1A.3.3.2), used in commercial vaccines, are in black. The pandemic vaccine strain A/California/04/2009(H1N1) is highlighted in cyan.