Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 11;10:4510. doi: 10.1038/s41598-020-61315-5

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Antigenic diversity of Chilean H1 swine IAVs. A three-dimensional antigenic map was constructed with cross-HI titers among ChH1A, H1ChB and A(H1N1)pdm09-like strains. All axes represent antigenic distance, and the orientation of the map within these axes is free. The spacing between grid lines is 1 unit of antigenic distance (antigenic unit or AU), corresponding to a 2-fold dilution of antiserum in the HI assay. Circles correspond to viruses and squares to antisera analyzed. Antigenic clusters were defined by Ward’s method based on the Euclidean distances among strains. Color represents the antigenic clusters: ChH1A is blue, ChH1B is purple, and A(H1N1)pdm09-like is green. The antisera from the strains A/swine/Chile/VN1401-274/2014(H1N2), A/swine/Chile/VN1401-4/2014(H1N2) and A/swine/Valparaiso/VN1401-559/2014(H1N1), highlighted as a red square, had the broadest cross-reactivity and, therefore, they were the nearest antisera to the center of the antigenic clusters ChH1A, ChH1B and A(H1N1)pdm09-like, respectively. Values in AU and red arrows show the distance between these central antisera and the outlying antigens (antigenic variants) in each cluster: A/swine/Chile/VN1401-339/2014(H1N2) (339), A/swine/Chile/VN1401-343/2014(H1N2) (343) and A/swine/Chile/VN1401-367/2014(H1N2) (367) from ChH1A, and A/swine/Rancagua/VN1401-1107/2015(H1N1) (1107), A/swine/Chillan/VN1401-1705/2015(H1N1) (1705) and A/swine/Chillan/VN1401-1719/2015(H1N1) (1719) from A(H1N1)pdm09-like.