Table 2.
Univariate analysis of disease free survival (DFS) or overall survival (OS).
| Characteristics | Hazards ratio (DFS)* (95% confidence interval) (N = 91) | P value (DFS) | Hazards ratio (OS) (95% confidence interval) (N = 104) | P value (OS) |
|---|---|---|---|---|
| Age | ||||
| 0.9983 (0.95–1.05) | 0.947 | 0.9691 (0.919–1.02) | 0.248 | |
| Gender | ||||
| Female | 1.000 (Reference) | 0.311 | 1.000 (Reference) | 0.236 |
| Male | 1.84 (0.566–5.98) | 2.231 (0.592–8.41) | ||
| Overall pathological stage (TNM) | ||||
| TisN0** + I–II | 1.000 (Reference) | 0.0362 | 1.000 (Reference) | 0.0341 |
| III–IV | 3.971 (1.09–14.4) | 9.235 (1.18–72.2) | ||
| Tumor size | ||||
| <2.5 cm | 1.000 (Reference) | 0.48 | 1.000 (Reference) | 0.217 |
| 2.5 cm – 5 cm | 3.316 (0.424–25.9) | 1.373 (0.16–11.8) | ||
| > 5 cm | 2.215 (0.201–24.4) | 3.707 (0.432–31.8) | ||
| Metastasis lymph node number | ||||
| <2 | 1.000 (Reference) | 0.00652 | 1.000 (Reference) | 0.0114 |
| ≥ 2 | 5.999 (1.65–21.8) | 14.23 (1.82–111) | ||
| Smoke | ||||
| No | 1.000 (Reference) | 0.118 | 1.000 (Reference) | 0.13 |
| Yes | 2.445 (0.798–7.49) | 2.587 (0.756–8.85) | ||
| Alcohol | ||||
| No | 1.000 (Reference) | 0.325 | 1.000 (Reference) | 0.433 |
| Yes | 1.73 (0.581–5.16) | 1.607 (0.49–5.27) | ||
| CEA (>5 ng/ml) | ||||
| No | 1.000 (Reference) | 0.08 | 1.000 (Reference) | 0.255 |
| Yes | 2.657 (0.89–7.93) | 1.993 (0.608–6.53) | ||
| Histological grade | ||||
| Well differentiated | 1.000 (Reference) | 0.349 | 1.000 (Reference) | 0.000103 |
| Poor differentiated | 2.055 (0.455–9.28) | 10.62 (3.22–35) | ||
| Splenic flexure | ||||
| Right | 1.000 (Reference) | 0.241 | 1.000 (Reference) | 0.783 |
| Left | 3.393 (0.441–26.1) | 1.24 (0.268–5.74) | ||
*Stage 4 patients were excluded in DFS analysis; **adenoma (T vs. N0).