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. 2020 Mar 11;10:4490. doi: 10.1038/s41598-020-61402-7

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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SET8 overexpression promotes proliferation, migration, and invasion of HCC cells. (A) CCK-8 assay showing that SET8 overexpression promotes proliferation of Huh-7 cells. (B) Quantification of results from A. (C) Wound healing assay showing that SET8 overexpression promotes migration of Huh-7 cells. (D) Quantification of results from C. (E) Transwell assay showing that SET8 overexpression stimulates invasion of Huh-7 cells. (F) Western blot showing the protein levels of SET8, p53 and p53K382me1 upon SET8 overexpression in Huh-7 cells. **p < 0.01, *p < 0.05.