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. 2020 Mar 11;11:1315. doi: 10.1038/s41467-020-14958-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Sema7a^loxP/loxPHBBCre+, Sema7a^loxP/loxPMyh6Cre+, Sema7a^loxP/loxPTie2Cre+, and Sema7a^loxP/loxPLysMCre+ animals or littermate controls were exposed to 60 min of ischemia and 120 min reperfusion. a Representative TTC-stained slices of myocardial tissue showing infarcted area (blue/dark = retrograde Evans blue staining; red and white = AAR, white = infarcted tissue) in Sema7a^loxP/loxPHBBCre+ or littermate controls with b systematic evaluation of infarct sizes (n = 7;8) and correlating troponin I plasma levels (n = 6;8). c Representative histology sections (scale bar 100 µm) of Sema7a^loxP/loxPHBBCre+ animals or littermate controls and d number of PNCs counted from myocardial AAR sections in Sema7a^loxP/loxPHBBCre+ animals or littermate controls (n = 9/group). e Representative TTC-stained slices of myocardial tissue showing infarcted area in Sema7a^loxP/loxPMyh6Cre+ or littermate controls with f systematic evaluation of infarct sizes and correlating troponin I plasma levels (n = 6;7). g Representative histological sections of Sema7a^loxP/loxPMyh6Cre+ animals or littermate controls (scale bar 100 µm) and h number of PNCs counted in myocardial tissue sections of Sema7a^loxP/loxPMyh6Cre+ animals or littermate controls (n = 9/group). i Representative TTC-stained heart slices showing myocardial infarcts in Sema7a^loxP/loxPTie2Cre+ or littermate controls with j systematic evaluation of infarct sizes (n = 6;5) and correlating troponin I plasma levels (n = 6;6). k Representative histology sections of Sema7a^lox/loxPTie2Cre+ animals or littermate controls (scale bar 100 µm) and l number of PNCs counted in myocardial tissue sections of Sema7a^loxP/loxPTie2Cre+ or littermate controls (n = 9/group). m Representative TTC-stained slices of myocardial tissue showing infarcted area in Sema7a^loxP/loxPLysMCre+ or littermate controls with n systematic evaluation of infarct sizes (n = 6/group) and correlating troponin I plasma levels (n = 8/group). o Representative histology sections of Sema7a^loxP/loxPLysMCre+ animals or littermate controls (scale bar 100 µm) and p number of PNCs counted from myocardial tissue sections of Sema7a^loxP/loxPLysMCre+ or littermate controls (n = 9/group). All comparisons in this figure were analyzed by unpaired two-tailed Student’s t-tests (data are mean ± SD). *p < 0.05, **p < 0.01 and ***p < 0.001 as indicated.