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. 2020 Mar 11;10:4484. doi: 10.1038/s41598-020-61416-1

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Progression-free and overall survival in relation to sTK1 activity levels. Kaplan-Meier curves displaying PFS and OS in patients with high versus low sTK1 activity levels based on the median sTK1 level cut-off at baseline (a,b), at 1 month (c,d), at 3 months (e,f) and at 6 months (g,h) during the first 6 months of systemic therapy for MBC. Analyses at 1, 3, and 6 months were performed using landmark analysis, in which the follow-up time was recalculated with a new starting date from the 1, 3, and 6-month sample date, respectively.