Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2020 Mar 5;8:133. doi: 10.3389/fcell.2020.00133

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

Copyright © 2020 Tweedy and Insall.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

PMC Copyright notice

Self-generated gradients are robust to population changes unless saturated with attractant. (A) Simulations of the uniform 10 μM condition, varying the number of cells introduced at the left-hand side. (B) D. discoideum responding to an initially uniform profile of 20 μM folate, varying the initial number of cells in the assay in twofold steps. (C) Distance traveled by real D. discoideum cells migrating toward a 20 μM (red) or 1 μM (blue) background of the degradable attractant folate. t-test of means across the front-most cells × 3 biological repeats show significant differences in position (p < 0.01) for both the lowest and highest two populations. (D) Simulations of a range of populations for a 10 μM (red) and 500 nM (blue) attractant background.