Figure 1.

RNA-seq analysis of control SS and SS.BN3 hearts. Total RNA was extracted and RNA-seq was performed on RNA from the left ventricle tissue of adult 10–12 week old female SS and SS.BN3 rats harvested 1 week after mock treatment (N = 4/group). Differential expression analysis was performed, followed by generation of heat maps of (A) 13 mitochondrial encoded genes and (B) 74 nuclear encoded genes differentially expressed at FDR < 0.05 and involved in the mitochondrial complexes that drive oxidative phosphorylation.