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. 2020 Mar 5;7:23. doi: 10.3389/fcvm.2020.00023

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Copyright © 2020 Schlaak, Frei, SenthilKumar, Tsaih, Wells, Mishra, Flister, Camara and Bergom.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Echocardiograms indicated SS rats have decreased heart function compared with SS.BN3 rats after 24 Gy localized heart RT. (A) M-mode echocardiogram images of SS and SS.BN3 rats that received 24 Gy RT at baseline, 3 months, and 5 months post -RT. (B) Radial strain was lower in the SS rats at 3 and 5 months post-RT shown via decreased thickening of myocardium. (C) Circumferential strain also showed decreased function in SS vs. SS.BN3 at 3 and 5 months post-RT via decreased ability to contract, indicated by a smaller negative percentage. Values are means ± SEM. ^*P < 0.01, ^#P < 0.001.