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. 2020 Mar 5;11:293. doi: 10.3389/fimmu.2020.00293

Figure 6.

Figure 6

Persistence of tau dephosphorylating effects of systemic LPS in hTau/mTau+/− mice at 24 h post-injection. Three-month-old male Wt, mTau+/−, and hTau/mTau−/− mice were challenged with LPS (250 μg/kg, i.v.) or its vehicle PBS. Their brains were collected 24 h later, immediately after assessment of sickness symptoms for the determination by western immunoblotting of hippocampal soluble phosphorylated tau at the pS202 and pS396/404 epitopes and total tau (tau 46) levels (A), PP2A activity (E), and whole brain insoluble total and phosphorylated tau (G). pS202 (B) and pS396/404 (C) tau dephosphorylation persisted for at least 24 h after LPS administration, while levels of total tau (D) and PP2A activity (F) remained unaltered. There was also no evidence of insoluble tau (G). Data are expressed as means ± SEM. Pairwise comparisons: *p < 0.05; **p < 0.01 vs. PBS.