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. 2020 Mar 5;11:221. doi: 10.3389/fphar.2020.00221

FIGURE 3.

FIGURE 3

Foot skin nerve profiles detected by immunofluorescence assay. (A–D) Representative images of immunofluorescence staining of hind paw plantar skin nerves. The yellow arrows point PGP 9.5 immuno-reactive intraepidermal nerve fiber (IENF) and the red arrows point subepidermal nerve fiber (SNF). Magnification: 20×, scale bars: 100 μm; (E) SNFD (fibers/mm); (F) IENFD (fibers/mm). Data are group mean ± SEM (n = 3 per group). *P < 0.05 and **P < 0.01 vs. control group; #P < 0.05 and ##P < 0.01 vs. untreated STZ group by ANOVA with Dunnett’s post-hoc test.