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. 2020 Mar 5;11:221. doi: 10.3389/fphar.2020.00221

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Copyright © 2020 Zhang, Song, Liang, Xie, Shi, Shi, Qiu and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Screening of serum metabolic biomarkers regulated by JMT decoction administration. (A,B) The score plots of OPLS-DA between Control (CON) vs. STZ groups (A1,B1), STZ vs. STZ + JMT-H groups (A2,B2), and STZ vs. STZ + JMT-L groups (A3,B3) in negative and positive ion modes, respectively (n = 6 per group). (C) Venn diagram illustrated the distinct and overlapping metabolites that commonly changed in different groups. The serum levels of 16 metabolites were found to be regulated toward normal by JMT decoction administration at both low and high dosage, while another 5 metabolites were regulated just by JMT decoction at high dosage.