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. 2020 Mar 5;11:221. doi: 10.3389/fphar.2020.00221

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Copyright © 2020 Zhang, Song, Liang, Xie, Shi, Shi, Qiu and Chen.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Serum levels of identified biomarkers in different group (A) and their correlations with DPN efficacy indicators (B, Von Frey; C, IENFD; D, SNFD) *P < 0.05, **P < 0.01, and ***P < 0.005. (B) Ten metabolites were significantly negatively correlated with Von Frey (P < 0.05). (C) Nine metabolites were significantly negatively correlated with IENFD (P < 0.05). (D) Seven metabolites were significantly negatively correlated with SNFD (P < 0.05).