Table 1.
Xenograft growth metrics.
| All xenografts | ||||||
|---|---|---|---|---|---|---|
| Overall | Gallbladder | iCCA | pCCA | dCCA | p value | |
| OPTR (%) | 47/87 (54.0) | 7/10 (70.0) | 23/41 (56.1) | 8/20 (40.0) | 9/16 (56.3) | 0.43 |
| Successful xenografts | ||||||
| Overall |
Gallbladder |
iCCA |
pCCA |
dCCA |
p value | |
| n = 47 | n = 7 | n = 23 | n = 8 | n = 9 | ||
| TTF (days) | 41 [26–84] | 34 [25–97] | 35 [23–82] | 60 [22–103] | 45 [40–107] | 0.50 |
| TTH (days) | 130 [84–172] | 169 [82–212] | 115 [75–162] | 168 [107–247] | 131 [92–173] | 0.36 |
| Engraftment efficiency | 0.6 [0.4–0.8] | 0.5 [0.35–0.75] | 0.6 [0.4–1] | 0.6 [0.45–0.6] | 0.7 [0.6–0.85] | 0.50 |
OPTR: Number of successful PDX models/number of patients.
TTF: Number of days from implantation to palpation of first tumor (approximately 8 mm3).
TTH: Number of days from implantation to harvest of first tumor (approximately 1,000 mm3).
Engraftment efficiency: Number of mice with successful engraftment/number of total mice implanted.
CCA, cholangiocarcinoma; dCCA, distal cholangiocarcinoma; iCCA, intrahepatic cholangiocarcinoma; OPTR, overall patient take rate; PDX, patient-derived xenograft; TTF, time to tumor formation; TTH, time to tumor harvest.