Table 2.
Patient and tumor characteristics.
| Unsuccessful engraftment (n = 40) |
Successful engraftment (n = 47) |
p value |
|
|---|---|---|---|
| n (%) | n (%) | ||
| Female | 21 (52.5) | 22 (46.8) | 0.60 |
| Median age at surgery [IQR] | 64.4 [53.3–73.4] | 54 [55.3–69] | 0.58 |
| Pathologic subtype | 0.43 | ||
| Gallbladder adenocarcinoma | 3 (7.5) | 7 (14.9) | |
| Intrahepatic cholangiocarcinoma | 18 (45.0) | 23 (48.9) | |
| Hilar cholangiocarcinoma | 12 (30.0) | 8 (17.0) | |
| Distal cholangiocarcinoma | 7 (17.5) | 9 (19.2) | |
| Neoadjuvant therapy | 0.22 | ||
| None | 33 (82.5) | 39 (83.0) | |
| Chemotherapy | 5 (12.5) | 7 (14.9) | |
| Radiation | 0 (0.0) | 1 (2.1) | |
| Chemotherapy and radiation | 2 (5.0) | 0 (0.0) | |
| Median initial CA19-9 [IQR] | 90.5 [26–210] | 53.5 [11.8–240.8] | 0.41 |
| Median pre-op CA19-9 [IQR]± | 38.0 [19–132] | 46.5 [24.0–97.3] | 0.50 |
| Procedure | 0.36 | ||
| Hepatectomy | 18 (45.0) | 24 (51.2) | |
| Biopsy (radiographic or in OR) | 10 (25.0) | 5 (10.6) | |
| Pancreatectomy | 4 (10.0) | 6 (12.8) | |
| Other | 8 (20.0) | 12 (25.6) | |
| Source of specimen | 0.03 | ||
| Operating room | 31 (77.5) | 44 (93.6) | |
| Radiographic biopsy | 9 (22.5) | 3 (6.4) | |
| Xenograft tissue obtained | 0.09 | ||
| Primary tumor | 28 (70.0) | 39 (83.0) | |
| Primary biopsy | 9 (22.5) | 3 (6.4) | |
| Metastatic lesion | 3 (7.5) | 5 (10.6) | |
| Median ischemic time [IQR] | 41 [31–66] | 61 [42–75] | 0.01 |
| Summary stage | 0.23 | ||
| 0 – II | 19 (48.7) | 29 (61.7) | |
| III – IV | 20 (51.3) | 18 (38.3) | |
| Resected tumors only (Biopsies and metastatic lesions excluded) |
(n = 28) | (n = 39) | p value |
| Positive margins | 0.06 | ||
| Yes | 6 (21.4) | 2 (5.1) | |
| No | 25 (78.6) | 37 (94.9) | |
| Lymphovascular invasion | 0.75 | ||
| Yes | 4 (14.3) | 7 (18.0) | |
| No | 24 (85.7) | 32 (82.0) | |
| Perineural invasion | 0.06 | ||
| Yes | 15 (53.6) | 11 (28.2) | |
| No | 13 (46.4) | 28 (71.8) | |
| Tumor differentiation | 0.95 | ||
| Well | 3 (10.7) | 4 (10.3) | |
| Moderate/Poor | 25 (89.3) | 35 (89.7) | |
| Mean positive node ratio (SD) | 0.12 (0.23) | 0.14 (0.23) | 0.79 |
| Median tumor size [IQR] | 4.5 [2.7–7.3] | 3.9 [2.5–5.6] | 0.41 |
Values in bold denote significance.
OR, operating room.
±
Values for patients who underwent neoadjuvant therapy only (n = 14).