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. 2020 Mar 11;10:4509. doi: 10.1038/s41598-020-60233-w

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Late-onset increased vascular permeability in experimental epidermolysis bullosa acquisita. (a,c) Mean (SEM) Evans blue elution (in relation to weight) in BALB/c (a) and C57BL/6J (c) mice injected s.c. with normal rabbit IgG (NR-IgG) or affinity-purified anti-COL7 IgG 4 (AP anti-COL7 IgG) days after the initial IgG injection. The induction of experimental experimental epidermolysis bullosa acquisita led to increased vascular permeability, which was evidenced by an increase in eluted Evans blue (*p < 0.05, t-test, n = 4–5 mice/group). (b,d) Representative clinical images of BALB/c (b) and C57BL/6J (d) mice injected with NR-IgG or AP anti-COL7 IgG and Evans blue.