Fig. 2.

Illustration of the five different types of multiparametric radiomics (mpRad) framework features based on first and second order statistical analysis. Left: Construction of representative breast tissue signatures on normal and lesion tissue. Right: mpRad features defined as the radiomic tissue signature first order statistics (TSFOS), tissue signature probability matrix (TSPM), and the tissue signature co-occurrence matrix (TSCM) features evaluate the complex interactions between different tissue signatures. The tissue signature complex interaction network (TSCIN) first order statistics and tissue signature relationship matrix (TSRM) features evaluate the inter-parameter complex interactions. The straight yellow arrows indicate the lesion tissue and the curved yellow arrow show glandular tissue